Endocrine Abstracts

Purpose: At the beginning of 2016, radiofrequency ablation of benign thyroid nodules began to be carried out at the Central University Hospital of Asturias (Spain). The aim of this study was to evaluate the results obtained by the moment with the aforementioned technique.Methods: It is a descriptive study carried out through the data obtained during the process and the subsequent analytical and ultrasonographic follow-up. In addition, patient surveys hav...

Objectives: Understanding and propagating the knowledge of the burden caused by the massive infradiagnosis of Primary Aldosteronism (PA), partly due to unawareness of its high prevalence and partly to the complexity of its screening in Primary Care and workup in Specialized Care.Methods: Review of the relevant literature and personal reflections.Results: PA is the first cause of secondary hypertension and a highly prevalent disease...

Purpose: Neuroendocrine neoplasms are known to have heterogeneous biological behavior. G3 neuroendocrine tumours (NET G3) are characterized by well-differentiated morphology and Ki67>20%. The prognosis of this disease is understood to be intermediate between NET G2 and neuroendocrine carcinoma (NEC). Clinical management of NET G3 is challenging due to limited data to inform treatment strategies.Methods: We describe clinical characteristics, treatment, an...

IntroductionCarney Complex is a rare syndrome characterized by lentiginosis cutis and/or blue nevi, multiple endocrine neoplasia and non-endocrine tumors (cutaneous, mucosal, mammary or cardiac myxomata, bone osteochondromyxoma, psammomatous melanotic schwannoma, multiple ovarian cysts, multiple mammary ductal adenoma). Most cases are familiar, with autosomal dominant heredity and penetrance close to 100%. It is caused by a variety of mutations that acti...

IntroductionMany transsexual patients are concerned about the risk of cancer associated with hormonal gender-affirming therapy. However, the general risk seems to be very low. We hereby report the case of a strikingly large gastrointestinal stromal tumor (GIST) in a male-to-female transsexual patient, after 25 years of hormonal therapy.MethodsReview of the patient’s clinical records and the relevant lite...

IntroductionVitamin D deficiency is associated with higher risk of COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (81.0% < 30 ng/ml plasma calcifediol) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown in Northern Gran Canaria. During the winter period (December 2020 to February 2021) some restrictions for social gatherings and a nightly curfew have been en...

ObjectivePresentation of multinodular goiter as an unusual feature in a patient with Williams-Beuren Syndrome.MethodsReview of the patient’s clinical records and of the relevant literature.IntroductionThe Williams-Beuren Syndrome is a multisystem disorder caused by a microdeletion of 1.5–1.8 megabase pairs on chromosome 7q11-123, with loss of 26–28 ...

Clinical vignette: We investigated a 33-year-old woman diagnosed during pregnancy with a 7cm unilateral adrenal mass associated with severe ACTH-independent glucocorticoid and androgen excess, a steroid phenotype usually indicative of adrenocortical carcinoma. Pregnancy had been achieved with in-vitro fertilisation on the assumption of underlying PCOS. Neonatal death occurred soon after emergency delivery due to foetal growth arrest at 26 weeks gestation. Hist...

Ntroduction and Aim: The use of sodium-glucose cotransporter type 2 (SGLT-2) inhibitors has importantly improved the management of patients with type 2 diabetes mellitus. The aim of the present study was to evaluate the renal and metabolic effects after one year of SGLT-2 use in a cohort of patients with type 1 diabetes mellitus (T1D) treated with continuous subcutaneous insulin infusion (CSII).Methods: Retrospective observational study in adult patients...

Background: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome. Primary unilateral macronodular adrenal hyperplasia with concomitant glucocorticoid and androgen excess has never been studied before.Methods: We investigated a woman with a large, heterogeneous 7 cm adrenal mass (with a radiologically normal contralateral adrenal) and adrenocorticotropic hormone (ACTH)-independent glucocorticoid and androge...